Sang-Heng Kok Selected Research

Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

3/2007	Tumor necrosis factor-alpha stimulates the expression of C-C chemokine ligand 2 gene in fibroblasts from the human nasal polyp through the pathways of mitogen-activated protein kinase.
11/2005	C-C chemokine ligand 2 gene expression in nasal polyp fibroblasts: possible implication in the pathogenesis of nasal polyposis.

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Sang-Heng Kok Research Topics

Disease

14	Neoplasms (Cancer) 01/2022 - 01/2002
12	Squamous Cell Carcinoma of Head and Neck 01/2022 - 01/2002
6	Osteonecrosis (Kienbock's Disease) 01/2022 - 12/2005
6	Periapical Periodontitis (Apical Periodontitis) 10/2021 - 02/2009
6	Hypoxia (Hypoxemia) 10/2021 - 05/2008
5	Mouth Neoplasms (Oral Cancer) 01/2022 - 01/2005
5	Bone Resorption 01/2020 - 01/2003
5	Arthritis (Polyarthritis) 03/2013 - 10/2008
4	Disease Progression 12/2018 - 04/2011
4	Lymphatic Metastasis 07/2015 - 01/2011
4	Experimental Arthritis 03/2013 - 10/2008
3	Carcinogenesis 08/2013 - 02/2002
3	Pain (Aches) 09/2011 - 04/2005
3	Nasal Polyps (Nasal Polyp) 05/2008 - 11/2005
1	Prostatic Neoplasms (Prostate Cancer) 01/2022
1	Anemia 01/2022
1	Neoplasm Metastasis (Metastasis) 01/2022
1	Osteoradionecrosis 01/2018
1	Infections 01/2018
1	Colorectal Neoplasms (Colorectal Cancer) 04/2017
1	Inflammation (Inflammations) 03/2017
1	Rheumatoid Arthritis 03/2013
1	Osteoporosis 01/2013
1	Metabolic Bone Diseases (Osteopenia) 01/2013
1	Mercury Poisoning (Poisoning, Mercury) 02/2011
1	Bone Diseases (Bone Disease) 05/2009
1	Carcinoma (Carcinomatosis) 08/2007
1	Mucormycosis 12/2005
1	Oral Lichen Planus 04/2005
1	Osteosarcoma (Osteogenic Sarcoma) 03/2004

Drug/Important Bio-Agent (IBA)

6	CytokinesIBA 01/2022 - 01/2003
6	Proteins (Proteins, Gene)FDA Link 08/2013 - 01/2002
5	Simvastatin (Zocor)FDA LinkGeneric 05/2013 - 05/2009
4	SirtuinsIBA 10/2021 - 03/2013
4	Therapeutic UsesIBA 01/2020 - 10/2008
3	Messenger RNA (mRNA)IBA 04/2017 - 05/2013
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2015 - 05/2008
3	Placenta Growth FactorIBA 05/2013 - 10/2010
3	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 11/2012 - 05/2008
2	Interleukin-6 (Interleukin 6)IBA 01/2022 - 03/2017
2	Bone Density Conservation AgentsIBA 01/2022 - 08/2021
2	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2021 - 03/2017
2	Zoledronic Acid (Zometa)FDA Link 08/2021 - 01/2013
2	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 12/2018
2	Poly Adenosine Diphosphate RiboseIBA 12/2018 - 10/2015
2	Lactic Acid (Lactate)FDA LinkGeneric 03/2017 - 10/2015
2	Lactate Dehydrogenase 5IBA 03/2017 - 10/2015
2	Alendronate (Alendronate Sodium)FDA LinkGeneric 12/2013 - 09/2011
2	Cysteine (L-Cysteine)FDA Link 12/2010 - 05/2009
2	Oncostatin MIBA 05/2009 - 03/2004
2	CC ChemokinesIBA 03/2007 - 11/2005
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2007 - 11/2005
2	LigandsIBA 03/2007 - 11/2005
2	LipopolysaccharidesIBA 03/2004 - 01/2003
1	Denosumab FDA Link 01/2022
1	CollagenIBA 01/2022
1	Cytochromes c (Cytochrome c)IBA 10/2021
1	Caspase 3 (Caspase-3)IBA 10/2021
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 10/2021
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2020
1	Conditioned Culture MediaIBA 01/2019
1	ChemokinesIBA 01/2019
1	Superoxides (Superoxide)IBA 12/2018
1	5- (6'- triphenylphosphoniumhexyl)- 5,6- dihydro- 6- phenyl- 3,8- phenanthridinediammineIBA 12/2018
1	Coloring Agents (Dyes)IBA 12/2018
1	Caspase 9IBA 12/2018
1	CytochromesIBA 12/2018
1	MetalsIBA 01/2018
1	Glutamine (L-Glutamine)FDA Link 04/2017
1	Glutamic Acid (Glutamate)FDA Link 04/2017
1	Glucose (Dextrose)FDA LinkGeneric 03/2017
1	Histone Deacetylases (Histone Deacetylase)IBA 03/2017
1	Biomarkers (Surrogate Marker)IBA 07/2015
1	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 05/2013
1	Sirtuin 1IBA 03/2013
1	Cysteine-Rich Protein 61IBA 03/2013
1	Beclin-1IBA 06/2012
1	deoxyuridine triphosphateIBA 06/2012
1	Teriparatide (Parathar)FDA Link 09/2011
1	Diphosphonates (Bisphosphonates)IBA 09/2011
1	MercuryIBA 02/2011
1	NeurotoxinsIBA 02/2011
1	esculetinIBA 12/2009
1	alpha- cyano- (3,4- dihydroxy)- N- benzylcinnamideIBA 05/2009
1	Janus Kinase InhibitorsIBA 05/2009
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 10/2008
1	Anesthetics (Anesthetic Agents)IBA 01/2008
1	SmokeIBA 08/2007
1	Mitogen-Activated Protein KinasesIBA 03/2007
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 04/2005
1	Irritants (Vesicants)IBA 04/2005
1	norcantharidinIBA 01/2005
1	Cantharidin (Cantharides)IBA 01/2005
1	Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA 01/2003

Therapy/Procedure

2	Therapeutics 08/2021 - 09/2011
2	Debridement 01/2020 - 12/2005
1	Neck Dissection (Radical Neck Dissection) 10/2016
1	Radiotherapy 10/2016
1	Intra-Articular Injections 03/2013
1	Conservative Treatment 01/2013